PUBLICATION
Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously
- Authors
- Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M.
- ID
- ZDB-PUB-061020-3
- Date
- 2006
- Source
- Development (Cambridge, England) 133(8): 1433-1443 (Journal)
- Registered Authors
- Hibi, Masahiko, Hirata, Tsutomu, Nakazawa, Masato, Yoshihara, Yoshihiro
- Keywords
- Fez, Zinc finger, Olfactory sensory neuron, Olfactory bulb, Axon guidance, Mitral cell, Interneuron, Rostral migratory stream, Mouse
- MeSH Terms
-
- Stem Cells/metabolism
- Zinc Fingers/genetics*
- Mice, Transgenic
- Cell Movement/genetics
- Crosses, Genetic
- Interneurons/cytology
- Cell Differentiation/genetics
- Nerve Tissue Proteins/biosynthesis
- Nerve Tissue Proteins/deficiency
- Nerve Tissue Proteins/genetics*
- Nerve Tissue Proteins/physiology
- Mice, Knockout
- Axonal Transport/genetics
- Signal Transduction/genetics
- Neurons, Afferent/cytology
- Neurons, Afferent/metabolism*
- Neurons, Afferent/physiology*
- Animals
- DNA-Binding Proteins/biosynthesis
- DNA-Binding Proteins/deficiency
- DNA-Binding Proteins/genetics*
- DNA-Binding Proteins/physiology
- Molecular Sequence Data
- Mice
- Male
- Olfactory Bulb/cytology
- Olfactory Bulb/embryology*
- Female
- Mice, Inbred C57BL
- PubMed
- 16540508 Full text @ Development
Citation
Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M. (2006) Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously. Development (Cambridge, England). 133(8):1433-1443.
Abstract
Fez is a zinc-finger gene encoding a transcriptional repressor that is expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. To reveal its function, we generated Fez-deficient mice. The Fez-deficient mice showed several abnormalities in the olfactory system: (1) impaired axonal projection of the olfactory sensory neurons; (2) reduced size of the olfactory bulb; (3) abnormal layer formation in the olfactory bulb; and (4) aberrant rostral migration of the interneuron progenitors. Fez was not expressed in the projection neurons, interneurons or interneuron progenitors. Transgene-mediated expression of Fez in olfactory sensory neurons significantly rescued the abnormalities in olfactory axon projection and in the morphogenesis of the olfactory bulb in Fez-knockout mice. Thus, Fez is cell-autonomously required for the axon termination of olfactory sensory neurons, and Fez non-cell-autonomously controls layer formation and interneuron development in the olfactory bulb. These findings suggest that signals from olfactory sensory neurons contribute to the proper formation of the olfactory bulb.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping