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ZFIN ID: ZDB-PUB-061020-3
Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously
Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M.
Date: 2006
Source: Development (Cambridge, England)   133(8): 1433-1443 (Journal)
Registered Authors: Hibi, Masahiko, Hirata, Tsutomu, Nakazawa, Masato, Yoshihara, Yoshihiro
Keywords: Fez, Zinc finger, Olfactory sensory neuron, Olfactory bulb, Axon guidance, Mitral cell, Interneuron, Rostral migratory stream, Mouse
MeSH Terms:
  • Animals
  • Axonal Transport/genetics
  • Cell Differentiation/genetics
  • Cell Movement/genetics
  • Crosses, Genetic
  • DNA-Binding Proteins/biosynthesis
  • DNA-Binding Proteins/deficiency
  • DNA-Binding Proteins/genetics*
  • DNA-Binding Proteins/physiology
  • Female
  • Interneurons/cytology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Molecular Sequence Data
  • Nerve Tissue Proteins/biosynthesis
  • Nerve Tissue Proteins/deficiency
  • Nerve Tissue Proteins/genetics*
  • Nerve Tissue Proteins/physiology
  • Neurons, Afferent/cytology
  • Neurons, Afferent/metabolism*
  • Neurons, Afferent/physiology*
  • Olfactory Bulb/cytology
  • Olfactory Bulb/embryology*
  • Signal Transduction/genetics
  • Stem Cells/metabolism
  • Zinc Fingers/genetics*
PubMed: 16540508 Full text @ Development
Fez is a zinc-finger gene encoding a transcriptional repressor that is expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. To reveal its function, we generated Fez-deficient mice. The Fez-deficient mice showed several abnormalities in the olfactory system: (1) impaired axonal projection of the olfactory sensory neurons; (2) reduced size of the olfactory bulb; (3) abnormal layer formation in the olfactory bulb; and (4) aberrant rostral migration of the interneuron progenitors. Fez was not expressed in the projection neurons, interneurons or interneuron progenitors. Transgene-mediated expression of Fez in olfactory sensory neurons significantly rescued the abnormalities in olfactory axon projection and in the morphogenesis of the olfactory bulb in Fez-knockout mice. Thus, Fez is cell-autonomously required for the axon termination of olfactory sensory neurons, and Fez non-cell-autonomously controls layer formation and interneuron development in the olfactory bulb. These findings suggest that signals from olfactory sensory neurons contribute to the proper formation of the olfactory bulb.