ZFIN ID: ZDB-PUB-060531-3
pyewacket, a new zebrafish fin pigment pattern mutant
Mellgren, E.M., and Johnson, S.L.
Date: 2006
Source: Pigment cell research   19(3): 232-238 (Journal)
Registered Authors: Johnson, Stephen L., Mellgren, Eve M.
Keywords: none
MeSH Terms:
  • Animals
  • Chromatophores/physiology
  • Melanocytes/physiology
  • Mutation*
  • Phenotype
  • Pigmentation/genetics*
  • Zebrafish/genetics*
  • Zebrafish/physiology
PubMed: 16704457 Full text @ Pig. Cell Res.
Many mutants that disrupt zebrafish embryonic pigment pattern have been isolated, and subsequent cloning of the mutated genes causing these phenotypes has contributed to our understanding of pigment cell development. However, few mutants have been identified that specifically affect development of the adult pigment pattern. Through a mutant screen for adult pigment pattern phenotypes, we identified pyewacket (pye), a novel zebrafish mutant in which development of the adult caudal fin pigment pattern is aberrant. Specifically, pye mutants have fin melanocyte pigment pattern defects and fewer xanthophores than wild-type fins. We mapped pye to an interval where a single gene, the zebrafish ortholog of the human gene DHRSX, is present. pye will be an informative mutant for understanding how xanthophores and melanocytes interact to form the pigment pattern of the adult zebrafish fin.