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ZFIN ID: ZDB-PUB-060526-3
A golden clue to human skin colour variation
Muller, J., and Kelsh, R.N.
Date: 2006
Source: BioEssays : news and reviews in molecular, cellular and developmental biology 28(6): 578-582 (Journal)
Registered Authors: Kelsh, Robert, Mueller, Jeanette
Keywords: none
MeSH Terms:
  • Animals
  • Color
  • Humans
  • Melanocytes/metabolism
  • Models, Genetic
  • Skin/metabolism
  • Skin Pigmentation/physiology*
PubMed: 16700060 Full text @ Bioessays
Variations in human skin pigmentation are obvious, but how have skin colour differences evolved? Although clearly a polymorphic trait, the number and identity of key variants has remained unclear. Investigation of pigmentation phenotypes in model organisms provides a route to identify these genes and showed MC1R to be one key locus. Now, cloning of a classic zebrafish mutant, golden, identifies slc24a5 as a gene involved in fish skin pigmentation.1 Strikingly this study identifies the human orthologue, SLC24A5, as likely to make a major contribution to the pale skin colouration of Western Europeans.