PUBLICATION
CC chemokines in zebrafish: Evidence for extensive intrachromosomal gene duplications
- Authors
- Peatman, E., and Liu, Z.
- ID
- ZDB-PUB-060517-28
- Date
- 2006
- Source
- Genomics 88(3): 381-385 (Journal)
- Registered Authors
- Keywords
- Chemokine, Cytokine, Immunity, Fish, Genome duplication, Zebrafish
- MeSH Terms
-
- Animals
- Chemokines, CC/genetics*
- Chromosomes/genetics*
- Evolution, Molecular*
- Gene Duplication*
- Multigene Family/genetics
- Zebrafish/genetics*
- Zebrafish Proteins/genetics*
- PubMed
- 16697551 Full text @ Genomics
Citation
Peatman, E., and Liu, Z. (2006) CC chemokines in zebrafish: Evidence for extensive intrachromosomal gene duplications. Genomics. 88(3):381-385.
Abstract
Chemokines are a family of structurally related chemotactic cytokines that regulate the migration of leukocytes. CC chemokines represent the largest subfamily of chemokines, with 28 genes in mammals. In recent studies in channel catfish, Ictalurus punctatus, we identified 26 distinct CC chemokine transcripts and obtained the genomic sequences and structures of 23 CC chemokine genes. However, without the availability of similar sets of CC chemokines in closely related species or a sequenced genome in catfish, it was difficult to make inferences as to the origins and modes of duplication of these molecules or to analyze conserved synteny between teleost and mammalian CC chemokines. Here, we have identified as many as 46 loci in the zebrafish genome that encode putative CC chemokines. The zebrafish CC chemokines are highly clustered on several chromosomes and show evidence of extensive, species-specific intrachromosomal duplications.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping