Mechanisms of ventral patterning in the vertebrate nervous system
- Lupo, G., Harris, W.A., and Lewis, K.E.
- Nature reviews. Neuroscience 7(2): 103-114 (Review)
- Registered Authors
- Harris, William A., Lewis, Katharine E.
- MeSH Terms
- Body Patterning/physiology*
- Embryonic Induction/physiology
- Gene Expression Regulation, Developmental
- Models, Neurological
- Nervous System/embryology*
- Signal Transduction/physiology*
- 16429120 Full text @ Nat Rev Neurosci
Lupo, G., Harris, W.A., and Lewis, K.E. (2006) Mechanisms of ventral patterning in the vertebrate nervous system. Nature reviews. Neuroscience. 7(2):103-114.
Dorsoventral patterning of the neural tube has a crucial role in shaping the functional organization of the CNS. It is well established that hedgehog signalling plays a key role in specifying ventral cell types throughout the neuroectoderm, and major progress has been made in elucidating how hedgehog signalling works in this ventral specification. In addition, other molecular pathways, including nodal, retinoic acid and fibroblast growth factor signalling, have been identified as important molecular cues for ventral patterning of the spinal cord, telencephalon and eye. Here, we discuss recent advances in this field, highlighting the emerging interplay of these signalling pathways in the molecular specification of ventral patterning at different rostrocaudal levels of the CNS.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes