PUBLICATION
The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration
- Authors
- Dufourcq, P., and Vriz, S.
- ID
- ZDB-PUB-060412-11
- Date
- 2006
- Source
- Development genes and evolution 216(10): 635-639 (Journal)
- Registered Authors
- Dufourcq, Pascale, Vriz, Sophie
- Keywords
- Regeneration, Progenitor cells, Chemokine, Sdf1, Cxcr4
- MeSH Terms
-
- Animals
- Chemokines, CXC/physiology*
- In Situ Hybridization
- Regeneration*
- Zebrafish/physiology*
- PubMed
- 16586100 Full text @ Dev. Genes Evol.
Citation
Dufourcq, P., and Vriz, S. (2006) The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration. Development genes and evolution. 216(10):635-639.
Abstract
The work presented in this study focuses on blastema formation in epimorphic regeneration. We describe the expression pattern of Sdf1a and Sdf1b (the chemokines stromal-cell-derived factor-1a and 1b) and their two receptors Cxcr4a and Cxcr4b during zebrafish fin regeneration. We demonstrate that Sdf1a/Cxcr4a plays a critical role in fin regeneration and more precisely in epidermal cell proliferation, an important process for blastema formation. In mammals, a single cxcr4 gene is involved both in chemotaxis and cell proliferation and survival; we discuss in this study a possible functional division of the two cxcr4 zebrafish genes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping