PUBLICATION
Reconstruction of a 450-My-old ancestral vertebrate protokaryotype
- Authors
- Kohn, M., Hogel, J., Vogel, W., Minich, P., Kehrer-Sawatzki, H., Graves, J.A., and Hameister, H.
- ID
- ZDB-PUB-060315-2
- Date
- 2006
- Source
- Trends in genetics : TIG 22(4): 203-210 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Evolution*
- Chickens/genetics
- Chromosome Painting/methods
- Fishes/genetics
- Humans
- Karyotyping/methods
- Phylogeny
- Tetraodontiformes/genetics
- Time Factors
- Vertebrates/genetics*
- Zebrafish/genetics
- PubMed
- 16517001 Full text @ Trends Genet.
Citation
Kohn, M., Hogel, J., Vogel, W., Minich, P., Kehrer-Sawatzki, H., Graves, J.A., and Hameister, H. (2006) Reconstruction of a 450-My-old ancestral vertebrate protokaryotype. Trends in genetics : TIG. 22(4):203-210.
Abstract
From recent work the putative eutherian karyotype from 100Mya has been derived. Here, we have applied a new in silico technique, electronic chromosome painting (E-painting), on a large data set of genes whose positions are known in human, chicken, zebrafish and pufferfish. E-painting identifies conserved syntenies in the data set, and it enables a stepwise reconstruction of the ancestral vertebrate protokaryotype comprising 11 protochromosomes. During karyotype evolution in land vertebrates interchromosomal rearrangements by translocation are relatively frequent, whereas the karyotypes of birds and fish are much more conserved. Although the human karyotype is one of the most conserved in eutherians, it can no longer be considered highly conserved from a vertebrate-wide perspective.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping