PUBLICATION

Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression

Authors
Lam, S.H., Wu, Y.L., Vega, V.B., Miller, L.D., Spitsbergen, J., Tong, Y., Zhan, H., Govindarajan, K.R., Lee, S., Mathavan, S., Krishna Murthy, K.R., Buhler, D.R., Liu, E.T., and Gong, Z.
ID
ZDB-PUB-051214-12
Date
2006
Source
Nat. Biotechnol.   24(1): 73-75 (Journal)
Registered Authors
Buhler, Donald R., Gong, Zhiyuan, Lam, Siew Hong, Spitsbergen, Jan, Tong, Yan, Wu, Yi Lian, Zhan, Huiqing
Keywords
none
Datasets
GEO:GSE3519
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Carcinogens
  • Conserved Sequence
  • Disease Progression
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic*
  • Liver Neoplasms, Experimental/chemically induced
  • Liver Neoplasms, Experimental/genetics*
  • Liver Neoplasms, Experimental/metabolism*
  • Molecular Sequence Data
  • Neoplasm Proteins/genetics*
  • Neoplasm Proteins/metabolism*
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Zebrafish/genetics*
  • Zebrafish/metabolism*
PubMed
16327811 Full text @ Nat. Biotechnol.
Abstract
The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes