ZFIN ID: ZDB-PUB-051214-12
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
Lam, S.H., Wu, Y.L., Vega, V.B., Miller, L.D., Spitsbergen, J., Tong, Y., Zhan, H., Govindarajan, K.R., Lee, S., Mathavan, S., Krishna Murthy, K.R., Buhler, D.R., Liu, E.T., and Gong, Z.
Date: 2006
Source: Nat. Biotechnol.   24(1): 73-75 (Journal)
Registered Authors: Buhler, Donald R., Gong, Zhiyuan, Lam, Siew Hong, Spitsbergen, Jan, Tong, Yan, Wu, Yi Lian, Zhan, Huiqing
Keywords: none
Microarrays: GEO:GSE3519
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Carcinogens
  • Conserved Sequence
  • Disease Progression
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic*
  • Liver Neoplasms, Experimental/chemically induced
  • Liver Neoplasms, Experimental/genetics*
  • Liver Neoplasms, Experimental/metabolism*
  • Molecular Sequence Data
  • Neoplasm Proteins/genetics*
  • Neoplasm Proteins/metabolism*
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Zebrafish/genetics*
  • Zebrafish/metabolism*
PubMed: 16327811 Full text @ Nat. Biotechnol.
The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.