PUBLICATION
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
- Authors
- Lam, S.H., Wu, Y.L., Vega, V.B., Miller, L.D., Spitsbergen, J., Tong, Y., Zhan, H., Govindarajan, K.R., Lee, S., Mathavan, S., Krishna Murthy, K.R., Buhler, D.R., Liu, E.T., and Gong, Z.
- ID
- ZDB-PUB-051214-12
- Date
- 2006
- Source
- Nat. Biotechnol. 24(1): 73-75 (Journal)
- Registered Authors
- Buhler, Donald R., Gong, Zhiyuan, Lam, Siew Hong, Spitsbergen, Jan, Tong, Yan, Wu, Yi Lian, Zhan, Huiqing
- Keywords
- none
- Datasets
- GEO:GSE3519
- MeSH Terms
-
- Zebrafish/genetics*
- Zebrafish/metabolism*
- Conserved Sequence
- Gene Expression Profiling
- Neoplasm Proteins/genetics*
- Neoplasm Proteins/metabolism*
- Animals
- Molecular Sequence Data
- Gene Expression Regulation, Neoplastic*
- Disease Progression
- Liver Neoplasms, Experimental/chemically induced
- Liver Neoplasms, Experimental/genetics*
- Liver Neoplasms, Experimental/metabolism*
- Sequence Homology, Amino Acid
- Species Specificity
- Amino Acid Sequence
- Carcinogens
- PubMed
- 16327811 Full text @ Nat. Biotechnol.
Citation
Lam, S.H., Wu, Y.L., Vega, V.B., Miller, L.D., Spitsbergen, J., Tong, Y., Zhan, H., Govindarajan, K.R., Lee, S., Mathavan, S., Krishna Murthy, K.R., Buhler, D.R., Liu, E.T., and Gong, Z. (2006) Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat. Biotechnol.. 24(1):73-75.
Abstract
The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping