PUBLICATION
Evolution of Hox Clusters in Salmonidae: A Comparative Analysis Between Atlantic Salmon (Salmo salar) and Rainbow Trout (Oncorhynchus mykiss)
- Authors
- Moghadam, H.K., Ferguson, M.M., and Danzmann, R.G.
- ID
- ZDB-PUB-051012-5
- Date
- 2005
- Source
- Journal of molecular evolution 61(5): 636-649 (Journal)
- Registered Authors
- Keywords
- Salmonid, Atlantic salmon, Hox genes, Genetic map
- MeSH Terms
-
- Animals
- Chromosome Mapping
- Evolution, Molecular*
- Genome/genetics
- Homeodomain Proteins/genetics*
- Molecular Sequence Data
- Multigene Family/genetics*
- Nucleotides/genetics
- Oncorhynchus kisutch/genetics*
- Phylogeny
- Salmo salar/genetics*
- PubMed
- 16205980 Full text @ J. Mol. Evol.
Citation
Moghadam, H.K., Ferguson, M.M., and Danzmann, R.G. (2005) Evolution of Hox Clusters in Salmonidae: A Comparative Analysis Between Atlantic Salmon (Salmo salar) and Rainbow Trout (Oncorhynchus mykiss). Journal of molecular evolution. 61(5):636-649.
Abstract
We studied the genomic organization of Hox genes in Atlantic salmon (Salmo salar) and made comparisons to that in rainbow trout (Oncorhynchus mykiss), another member of the family Salmonidae. We used these two species to test the hypothesis that the Hox genes would provide evidence for a fourth round of duplication (4R) of this gene family given the recent polyploid ancestry of the salmonid fish. Thirteen putative Hox clusters were identified and 10 of these complexes were localized to the current Atlantic salmon genetic map. Syntenic regions with the rainbow trout linkage map were detected and further homologies and homeologies are suggested. We propose that the common ancestor of Atlantic salmon and rainbow trout possessed at least 14 clusters of Hox genes, and additional clusters cannot be ruled out. Salmonid Hox cluster complements seem to be more similar to those of zebrafish (Danio rerio) than medaka (Oryzias latipes) or pufferfish (Sphoeroides nephelus and Takifugu rubripes), as both Atlantic salmon and rainbow trout have retained HoxCb ortholog, which has been lost in medaka and pufferfish but not in zebrafish. However, our data suggest that phylogenetically, the homologous genes within each cluster express mosaic relationships among the teleosts tested and, thus, leave unresolved the interfamilial relationships among these taxa.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping