ZFIN ID: ZDB-PUB-051012-27
Expression of the zebrafish Iroquois genes during early nervous system formation and patterning
Lecaudey, V., Anselme, I., Dildrop, R., Ruther, U., and Schneider-Maunoury, S.
Date: 2005
Source: The Journal of comparative neurology   492(3): 289-302 (Journal)
Registered Authors: Anselme, Isabelle, Lecaudey, Virginie, Schneider-Maunoury, Sylvie
Keywords: midbrain, hindbrain, diencephalon, neurogenesis, cranial placodes, homeodomain transcription factors
MeSH Terms:
  • Animals
  • Body Patterning*
  • Central Nervous System*/anatomy & histology
  • Central Nervous System*/embryology
  • Cloning, Molecular
  • Embryonic Structures/anatomy & histology
  • Embryonic Structures/metabolism
  • Gene Expression Regulation, Developmental*
  • Homeodomain Proteins/genetics*
  • Homeodomain Proteins/metabolism
  • In Situ Hybridization
  • Morphogenesis*
  • Multigene Family
  • Neurons/cytology
  • Neurons/metabolism
  • Protein Isoforms/genetics
  • Protein Isoforms/metabolism
  • Stem Cells/cytology
  • Stem Cells/metabolism
  • Zebrafish*/embryology
  • Zebrafish*/genetics
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
PubMed: 16217788 Full text @ J. Comp. Neurol.
Iroquois genes are involved in many patterning processes during development. In particular, they act as prepattern genes to control proneural gene expression both in Drosophila and in vertebrates. In this paper, we have analyzed the expression during embryogenesis of the 11 zebrafish Iroquois genes, with special interest for nervous system formation and patterning. During the first 2 days of development, Iroquois genes are expressed in distinct domains in the neuroepithelium, as well as in groups of neuronal progenitors and neurons. They are also expressed at different stages of placodal development. These expression patterns are similar to the patterns of the murine irx genes and also show features specific to teleosts. For the zebrafish Iroquois gene family, we find both specific patterns and patterns conserved within a cluster, between paralogues, or in most genes of the family. Overall, these expression data suggest functions for the Iroquois family of transcription factors in neural and placodal patterning, neurogenesis, and neuronal specification.