PUBLICATION
Off limits - Integrins holding boundaries in somitogenesis
- Authors
- Chong, S.W., and Jiang, Y.J.
- ID
- ZDB-PUB-050810-13
- Date
- 2005
- Source
- Trends in cell biology 15(9): 453-457 (Journal)
- Registered Authors
- Chong, Shang Wei, Jiang, Yun-Jin
- Keywords
- none
- MeSH Terms
-
- Animals
- Ephrins/physiology
- Epithelium/embryology
- Fibronectins/physiology
- Homeodomain Proteins/physiology
- Integrin alpha5/physiology
- Integrins/physiology*
- Nerve Tissue Proteins/physiology
- Receptor, Notch1/physiology
- Receptors, Eph Family/physiology
- Somites/physiology*
- Zebrafish/embryology*
- Zebrafish Proteins/physiology
- PubMed
- 16087338 Full text @ Trends Cell Biol.
Citation
Chong, S.W., and Jiang, Y.J. (2005) Off limits - Integrins holding boundaries in somitogenesis. Trends in cell biology. 15(9):453-457.
Abstract
Borders are essential for demarcating repeated structures such as somites during vertebrate development. Two recent articles describe roles for Integrinalpha5 and its ligand Fibronectin1 in zebrafish anterior intersomitic boundary formation and link them to Notch and Eph-Ephrin pathways in epithelialization of somite boundary cells. Together with these pathways, Integrinalpha5 and Fibronectin1 orchestrate the orderly formation of somite and later myotome borders. These studies shed light on components downstream of the periodic segmentation mechanism - the 'segmentation clock' - in somitogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping