PUBLICATION
Animal Models of Disease
- Authors
- Ma, C.
- ID
- ZDB-PUB-050712-2
- Date
- 2004
- Source
- Modern Drug Discovery 7(6): 30-36 (Review)
- Registered Authors
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none
Citation
Ma, C. (2004) Animal Models of Disease. Modern Drug Discovery. 7(6):30-36.
Abstract
In vivo assays are not usually performed until or after lead optimization is complete. This is partly due to the low speed and high cost of conventional animal models (typically rodents) and the relatively high number of preliminary hits from HTS. With alternative small-animal models emerging, however, it is now possible to perform in vivo testing earlier in the process. Thus, researchers have developed model systems using both invertebrates (the fruit fly and the nematode) and vertebrates (zebrafish) for drug screening. The small size, high fecundity, and experimental tractability of these animals enable cost-effective and rapid screening of numerous compounds.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping