PUBLICATION
Agouti-Related Proteins (AGRPs) and Agouti-Signaling Peptide (ASIP) in Fish and Chicken
- Authors
- Klovins, J., and Schiöth, H.B.
- ID
- ZDB-PUB-050518-8
- Date
- 2005
- Source
- Annals of the New York Academy of Sciences 1040: 363-367 (Journal)
- Registered Authors
- Keywords
- evolution; ASIP; AGRP; ACTH; fish
- MeSH Terms
-
- Agouti Signaling Protein
- Agouti-Related Protein
- Amino Acid Sequence
- Animals
- Chickens/genetics*
- Databases, Genetic
- Fishes/genetics*
- Intercellular Signaling Peptides and Proteins/genetics*
- Molecular Sequence Data
- Phylogeny
- Proteins/genetics*
- Species Specificity
- PubMed
- 15891063 Full text @ Ann N Y Acad Sci
Citation
Klovins, J., and Schiöth, H.B. (2005) Agouti-Related Proteins (AGRPs) and Agouti-Signaling Peptide (ASIP) in Fish and Chicken. Annals of the New York Academy of Sciences. 1040:363-367.
Abstract
We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C-terminal part of agouti-related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two from Fugu (Takifugu rubripes), and three from Tetraodon (Tetraodon nigroviridis). We have thus shown for the first time that both AGRP and ASIP genes exist in many species in "lower vertebrates" and were most probably present in early stages of vertebrate evolution.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping