PUBLICATION
High Species Variation within the Repertoire of Trace Amine Receptors
- Authors
- Gloriam, D.E., Bjarnadóttir, T.K., Schiöth, H.B., and Fredriksson, R.
- ID
- ZDB-PUB-050518-7
- Date
- 2005
- Source
- Annals of the New York Academy of Sciences 1040: 323-327 (Journal)
- Registered Authors
- Fredriksson, Robert
- Keywords
- evolution; GPCRs; trace amine receptors; zebrafish; pufferfish
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Genetic Variation/genetics*
- Humans
- Molecular Sequence Data
- Multigene Family*
- Phylogeny
- Receptors, G-Protein-Coupled/chemistry*
- Receptors, G-Protein-Coupled/genetics*
- Species Specificity
- PubMed
- 15891052 Full text @ Ann N Y Acad Sci
Citation
Gloriam, D.E., Bjarnadóttir, T.K., Schiöth, H.B., and Fredriksson, R. (2005) High Species Variation within the Repertoire of Trace Amine Receptors. Annals of the New York Academy of Sciences. 1040:323-327.
Abstract
Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping