PUBLICATION

Trends in the evolution of the proenkephalin and prodynorphin genes in gnathostomes

Authors
Khalap, A., Bagrosky, B., Lecaude, S., Youson, J., Danielson, P., and Dores, R.M.
ID
ZDB-PUB-050518-4
Date
2005
Source
Annals of the New York Academy of Sciences   1040: 22-37 (Journal)
Registered Authors
Keywords
proenkephalin; prodynorphin; molecular evolution; enkephalin; dynorphin
MeSH Terms
  • Phylogeny
  • Protein Precursors/genetics*
  • Molecular Sequence Data
  • Amino Acid Sequence
  • Enkephalins/genetics*
  • Gnathostoma/genetics*
  • Base Sequence
  • Animals
  • Evolution, Molecular*
(all 9)
PubMed
15891003 Full text @ Ann N Y Acad Sci
Abstract
The opioid/orphanin gene family provides a model system for analyzing the outcomes of genome duplication events. Recent studies on the proenkephalin gene provide additional evidence that the organizational plan for this gene has been conserved throughout the extensive radiation of the gnathostome vertebrates. However, an analysis of the amino acid sequence of proenkephalin from the zebrafish, Danio rerio, suggests that novel forms of this opioid precursor may be evolving in teleosts. Analyses of sarcopterygian prodynorphin sequences revealed a proenkephalin signature in prodynorphin. Current studies on the opioid/orphanin gene family point to the duplication events that shaped this family occurring prior to the radiation of the gnathostomes.
Genes / Markers
Figures
No images available
Expression
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
No data available
Fish
No data available
Antibodies
No data available
Orthology
No data available
Engineered Foreign Genes
No data available
Mapping
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Citation
Khalap, A., Bagrosky, B., Lecaude, S., Youson, J., Danielson, P., and Dores, R.M. (2005) Trends in the evolution of the proenkephalin and prodynorphin genes in gnathostomes. Annals of the New York Academy of Sciences. 1040:22-37.