PUBLICATION

Ray-Fin Fish Tetraploidization Gave Rise to Pufferfish Duplicates of NPY and PYY, but Zebrafish NPY Duplicate Was Lost

Authors
Sundström, G., Larsson, T.A., Brenner, S., Venkatesh, B., and Larhammar, D.
ID
ZDB-PUB-050518-11
Date
2005
Source
Annals of the New York Academy of Sciences   1040: 476-478 (Journal)
Registered Authors
Larhammar, Dan, Larsson, Tomas A., Sundström, Görel, Venkatesh, Byrappa
Keywords
NPY; PYY; PY; pufferfish; fugu; zebrafish; duplication; peptide
MeSH Terms
  • Animals
  • Humans
  • Zebrafish/genetics*
  • Peptide YY/genetics*
  • Takifugu/genetics*
  • Neuropeptide Y/genetics*
  • Species Specificity
  • Polyploidy
  • Genes, Duplicate/genetics*
(all 9)
PubMed
15891094 Full text @ Ann N Y Acad Sci
Abstract
We have used sequence information and gene location to identify NPY family genes in the pufferfish, Takifugu rubripes (fugu), and zebrafish. Fugu has two copies of NPY, presumably resulting from the ray-fin fish tetraploidization. Zebrafish has probably lost one of the copies. Both species have two copies of PYY, the second of which was previously named PY. The two fugu NPY genes are predominantly expressed in brain. The two PYY genes are expressed in a broad range of tissues including brain and gonads. Thus, the NPY system appears to be more complex in teleosts than in tetrapods.
Genes / Markers
Figures
No images available
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Citation
Sundström, G., Larsson, T.A., Brenner, S., Venkatesh, B., and Larhammar, D. (2005) Ray-Fin Fish Tetraploidization Gave Rise to Pufferfish Duplicates of NPY and PYY, but Zebrafish NPY Duplicate Was Lost. Annals of the New York Academy of Sciences. 1040:476-478.