ZFIN ID: ZDB-PUB-050506-3
The role of hedgehog signaling in the development of the zebrafish visual system
Stadler, J.A., Shkumatava, A., and Neumann, C.J.
Date: 2004
Source: Developmental neuroscience   26(5-6): 346-351 (Journal)
Registered Authors: Neumann, Carl J.
Keywords: none
MeSH Terms:
  • Animals
  • Brain/embryology*
  • Brain/physiology
  • Cell Communication
  • Cell Differentiation/physiology
  • Hedgehog Proteins
  • Models, Animal
  • Retina/embryology*
  • Retina/physiology
  • Signal Transduction/physiology*
  • Trans-Activators/genetics
  • Trans-Activators/metabolism*
  • Visual Pathways/embryology*
  • Visual Pathways/physiology
  • Zebrafish/embryology*
  • Zebrafish/physiology
PubMed: 15855763 Full text @ Dev. Neurosci.
The vertebrate visual system is a region of the nervous system that is characterized by relative simplicity, and its development has hence been studied intensively, to serve as a paradigm for the rest of the central nervous system. The zebrafish model organism offers an impressive array of tools to dissect this process experimentally, and in recent years has helped to significantly deepen our understanding of the development of the visual system. A number of these studies have focused on the role of the Hedgehog family of secreted signaling molecules in eye development, and this is the main topic of this review. Hedgehog signaling plays an important role in all major steps of visual system development, starting with the regionalization of the eye primordium into proximal and distal territories, continuing with the control of cellular differentiation in the retina, and ending with the guidance of axonal projections from the retina to the optic centers of the brain. Copyright 2004 S. Karger AG, Basel.