PUBLICATION

Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization

Authors
Kluver, N., Kondo, M., Herpin, A., Mitani, H., and Schartl, M.
ID
ZDB-PUB-050413-11
Date
2005
Source
Development genes and evolution   215(6): 297-305 (Journal)
Registered Authors
Schartl, Manfred
Keywords
Genome duplication, Subfunctionalization, Sox9, Chondrogenesis, Sex determination, Macroevolution
MeSH Terms
  • Animals
  • Gene Expression Profiling
  • Cell Lineage*
  • Zebrafish/genetics
  • Oryzias/embryology
  • Oryzias/genetics*
  • Embryonic Development
  • Molecular Sequence Data
  • Amino Acid Sequence
  • Phylogeny
  • Sequence Alignment
  • Nucleic Acid Hybridization
  • Genes, Duplicate*
  • High Mobility Group Proteins/chemistry
  • High Mobility Group Proteins/genetics*
  • High Mobility Group Proteins/metabolism
  • SOX9 Transcription Factor
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/metabolism
  • Gene Expression Regulation, Developmental*
  • Transcription Factors/chemistry
  • Transcription Factors/genetics*
  • Transcription Factors/metabolism
  • Genetic Linkage
PubMed
15818483 Full text @ Dev. Genes Evol.
Abstract
Sry-related HMG-box genes are key regulators of several developmental processes. Sox9 encodes a transcription factor required for cartilage formation and testis determination in mammals. In zebrafish (Danio rerio) and stickleback (Gasterosteus aculeatus) two co-orthologs of Sox9 are present. To date, only one Sox9 had been identified in medaka (Oryzias latipes). We have now isolated the second Sox9 gene. Sequence analysis, phylogenetic data, linkage mapping as well as expression pattern all together suggest that the medaka Sox9a and Sox9b are co-orthologs. During embryogenesis, the expression pattern of Sox9a and Sox9b are distinct but overlap considerably in craniofacial cartilage elements. Comparing the zebrafish Sox9a and Sox9b expression patterns with medaka Sox9a and Sox9b expression domains revealed that some are identical but others are clearly different. We conclude that Sox9 regulatory subfunctions were not partitioned before divergence of the teleosts and evolved to lineage-specific expression domains.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping