PUBLICATION
The neuronal growth and regeneration associated Cntn1 (F3/F11/Contactin) gene is duplicated in fish: expression during development and retinal axon regeneration
- Authors
- Haenisch, C., Diekmann, H., Klinger, M., Gennarini, G., Kuwada, J.Y., and Stuermer, C.A.
- ID
- ZDB-PUB-050209-5
- Date
- 2005
- Source
- Molecular and cellular neurosciences 28(2): 361-374 (Journal)
- Registered Authors
- Diekmann, Heike, Klinger, Michael, Kuwada, John, Stuermer, Claudia
- Keywords
- none
- MeSH Terms
-
- Phylogeny
- Nerve Regeneration/physiology*
- Sequence Homology, Nucleic Acid
- Organ Culture Techniques
- Species Specificity
- Up-Regulation/physiology
- Motor Neurons/cytology
- Motor Neurons/metabolism
- Cell Differentiation/physiology
- Zebrafish
- Optic Nerve/cytology
- Optic Nerve/embryology*
- Optic Nerve/metabolism
- Evolution, Molecular
- Animals
- Molecular Sequence Data
- Zebrafish Proteins
- Central Nervous System/cytology
- Central Nervous System/embryology*
- Central Nervous System/metabolism
- Goldfish
- Takifugu
- Cell Adhesion Molecules, Neuronal/genetics
- Cell Adhesion Molecules, Neuronal/metabolism*
- Conserved Sequence
- Contactin 1
- Contactins
- Oligodendroglia/metabolism
- Gene Expression Regulation, Developmental/physiology
- Retinal Ganglion Cells/cytology
- Retinal Ganglion Cells/metabolism*
- Protein Isoforms/genetics
- Protein Isoforms/metabolism
- Neurons, Afferent/cytology
- Neurons, Afferent/metabolism
- PubMed
- 15691716 Full text @ Mol. Cell Neurosci.
Citation
Haenisch, C., Diekmann, H., Klinger, M., Gennarini, G., Kuwada, J.Y., and Stuermer, C.A. (2005) The neuronal growth and regeneration associated Cntn1 (F3/F11/Contactin) gene is duplicated in fish: expression during development and retinal axon regeneration. Molecular and cellular neurosciences. 28(2):361-374.
Abstract
The Cntn1 (Contactin/F3/F11) cell adhesion molecule is involved in axon growth and guidance, fasciculation, synapse formation, and myelination in birds and mammals. We identified Cntn1 genes in goldfish, zebrafish, and fugu, and provide evidence for a fish-specific duplication leading to Cntn1a and Cntn1b. Our analyses suggest a subfunctionalization for the Cntn1 paralogs in zebrafish compared to other vertebrates which have a single Cntn1 gene. Similar to Cntn1a, Cntn1b transcripts are found in subsets of sensory and motor neurons. However, Cntn1b is detected later and more restricted than Cntn1a. This spatio-temporal expression pattern of the two zebrafish Cntn1 paralogs suggests functions related to those of mammalian Cntn1. In adult goldfish, Cntn1b is expressed in oligodendrocytes and is upregulated in retinal ganglion cells after optic nerve transection, which is consistent with an additional role during regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping