PUBLICATION
Responses of Muller glia to retinal injury in adult zebrafish
- Authors
- Yurco, P., and Cameron, D.A.
- ID
- ZDB-PUB-050209-11
- Date
- 2005
- Source
- Vision Research 45(8): 991-1002 (Journal)
- Registered Authors
- Cameron, David A.
- Keywords
- Regeneration; Retina; Proliferation; Apoptosis
- MeSH Terms
-
- Retina/cytology
- Retina/injuries*
- Zebrafish
- Neuroglia/cytology
- Neuroglia/physiology*
- Animals
- Nerve Regeneration*
- Mitosis
- Cell Division
- Apoptosis
- Stem Cells/cytology
- PubMed
- 15695184 Full text @ Vision Res.
Citation
Yurco, P., and Cameron, D.A. (2005) Responses of Muller glia to retinal injury in adult zebrafish. Vision Research. 45(8):991-1002.
Abstract
In an effort to identify the cellular events that enable neuronal regeneration in the vertebrate retina, the identity and characteristics of mitotic and apoptotic cells were examined in lesioned retinas of adult zebrafish. Following lesion a complex spatiotemporal pattern of mitosis was observed, including a delayed entry of Muller glia into the cell cycle. Characteristics of these proliferative Muller glia indicated they might serve as a stem/precursor cell of regenerated retina. The results suggested a model of retinal regeneration in which lesions are filled, in part, by a localized en place cytogenesis within intact retina surrounding the lesion site.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping