PUBLICATION
Kidney Development and Disease in the Zebrafish
- Authors
- Drummond, I.A.
- ID
- ZDB-PUB-050119-3
- Date
- 2005
- Source
- Journal of the American Society of Nephrology : JASN 16(2): 299-304 (Review)
- Registered Authors
- Drummond, Iain
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Embryonic Structures/ultrastructure*
- Genomics
- Humans
- Kidney/embryology*
- Models, Animal
- Nephrons/embryology*
- Nephrons/ultrastructure
- Organogenesis/physiology*
- Polycystic Kidney Diseases/embryology
- Polycystic Kidney Diseases/genetics*
- Species Specificity
- Zebrafish
- PubMed
- 15647335 Full text @ J. Am. Soc. Nephrol.
Citation
Drummond, I.A. (2005) Kidney Development and Disease in the Zebrafish. Journal of the American Society of Nephrology : JASN. 16(2):299-304.
Abstract
Unraveling the molecular pathogenesis of human disease presents many experimental challenges, not the least of which is that experiments on humans are generally frowned upon. Model organisms, including the zebrafish, allow for experimental analysis of gene function and the detailed characterization of disease processes. Zebrafish have matured as a vertebrate model organism now that genetic tools for targeted "knockdowns" and unbiased mutagenesis approaches are in hand. The fish larval pronephros is a relevant kidney in which to pursue many aspects of human kidney development and disease. This short review outlines recent progress in applying the zebrafish pronephros to issues of human health and development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping