PUBLICATION

Identification of novel genes coding for small expressed RNAs

Authors
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., and Tuschl, T.
ID
ZDB-PUB-041229-2
Date
2001
Source
Science (New York, N.Y.)   294(5543): 853-858 (Journal)
Registered Authors
Keywords
none
MeSH Terms
  • Organ Specificity
  • RNA, Untranslated/chemistry*
  • RNA, Untranslated/genetics*
  • RNA, Untranslated/metabolism
  • Drosophila melanogaster/embryology
  • Drosophila melanogaster/genetics
  • Cloning, Molecular
  • Computational Biology
  • RNA Precursors/chemistry
  • RNA Precursors/genetics
  • RNA Precursors/metabolism
  • Animals
  • Gene Expression Regulation*
  • Evolution, Molecular
  • Humans
  • Gene Expression Profiling
  • Multigene Family
  • Cell Line
  • Conserved Sequence
  • HeLa Cells
  • Blotting, Northern
  • Gene Expression Regulation, Developmental
  • Nucleic Acid Conformation
  • RNA/chemistry*
  • RNA/genetics*
  • RNA/metabolism
  • Base Pairing
(all 27)
PubMed
11679670 Full text @ Science
Abstract
In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs (stRNAs). We show that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs, similar to let-7 stRNA, are highly conserved. This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.
Genes / Markers
Figures
No images available
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., and Tuschl, T. (2001) Identification of novel genes coding for small expressed RNAs. Science (New York, N.Y.). 294(5543):853-858.