ZFIN ID: ZDB-PUB-041111-5
Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition
Rentzsch, F., Bakkers, J., Kramer, C., and Hammerschmidt, M.
Date: 2004
Source: Developmental dynamics : an official publication of the American Association of Anatomists   231(4): 750-757 (Journal)
Registered Authors: Bakkers, Jeroen, Hammerschmidt, Matthias, Rentzsch, Fabian
Keywords: neural induction, Fgf, Bmp, Noggin, Np63, zebrafish
MeSH Terms:
  • Animals
  • Bone Morphogenetic Proteins/genetics
  • Bone Morphogenetic Proteins/metabolism*
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism
  • Ectoderm/physiology*
  • Embryo, Nonmammalian/embryology
  • Embryo, Nonmammalian/physiology
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/metabolism*
  • Gene Expression Regulation, Developmental
  • Nervous System/embryology*
  • Nervous System/metabolism
  • Signal Transduction/physiology*
  • Smad Proteins
  • Trans-Activators/genetics
  • Trans-Activators/metabolism
  • Zebrafish
PubMed: 15532058 Full text @ Dev. Dyn.
Whereas according to the neural default model, neural specification is induced by extracellular inhibitors of bone morphogenetic proteins (Bmps), the role of fibroblast growth factors (Fgfs) during neural induction is heavily debated. Here, we show that, in zebrafish embryos, Bmps and Fgfs play differential roles during the induction and patterning of the anterior vs. the posterior neuroectoderm. Induction of anterior neuroectoderm, giving rise to fore- and midbrain, is accomplished by Bmp inhibition, with Fgfs playing a moderate posteriorizing/patterning role, possibly by blocking Bmp signaling at the level of Smad proteins. In contrast, in the posterior-most neuroectoderm, which is located in marginal regions of the early gastrula embryo to give rise to spinal cord and hindbrain, Fgfs play a neural-inducing rather than a neural-patterning role. This Fgf-dependent posterior neural induction takes place during late blastula and early gastrula stages, after mesoderm has been induced and cannot be blocked by Bmps or the Bmp target gene and downstream effector DeltaNp63alpha, indicating that here, Fgfs act independently of Bmp signaling inhibition. Developmental Dynamics, 2004. (c) 2004 Wiley-Liss, Inc.