PUBLICATION
gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish
- Authors
- Cheesman, S.E., and Eisen, J.S.
- ID
- ZDB-PUB-041111-21
- Date
- 2004
- Source
- Gene expression patterns : GEP 5(1): 107-112 (Journal)
- Registered Authors
- Cheesman, Sarah, Eisen, Judith S.
- Keywords
- Danio rerio; CNS; Mesencephalon; msxb; Diencephalon; Pax2; shh; Rhombomere 3
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Homeodomain Proteins/genetics*
- Homeodomain Proteins/metabolism
- Hypothalamus/embryology*
- Hypothalamus/metabolism
- Molecular Sequence Data
- Spinal Cord/embryology*
- Spinal Cord/metabolism
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 15533825 Full text @ Gene Expr. Patterns
Citation
Cheesman, S.E., and Eisen, J.S. (2004) gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish. Gene expression patterns : GEP. 5(1):107-112.
Abstract
We have cloned and characterized the expression of zebrafish genetic screen homeobox 1 (gsh1). Early expression is confined to hindbrain rhombomeres; by mid-somitogenesis gsh1 is expressed in precise domains within the mesencephalon and diencephalon, as well as in intermediate spinal cord. Double-label experiments revealed that the diencephalic domain is coincident with hypothalamus and that spinal cord expression is in a region that generates interneurons. These data suggest gsh1 may play a role in patterning cell types generated in these domains.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping