PUBLICATION

Divide et Impera – the midbrain–hindbrain boundary and its organizer

Authors
Raible, F., and Brand, M.
ID
ZDB-PUB-041101-5
Date
2004
Source
Trends in neurosciences   27(12): 727-734 (Review)
Registered Authors
Brand, Michael, Raible, Florian
Keywords
none
MeSH Terms
  • Animals
  • Biological Evolution
  • Gene Expression Regulation, Developmental
  • Growth Substances/metabolism
  • Mesencephalon*/anatomy & histology
  • Mesencephalon*/embryology
  • Mesencephalon*/physiology
  • Morphogenesis
  • Neurons/physiology
  • Organizers, Embryonic*
  • Rhombencephalon*/anatomy & histology
  • Rhombencephalon*/embryology
  • Rhombencephalon*/physiology
  • Signal Transduction/physiology
PubMed
15541513 Full text @ Trends Neurosci.
Abstract
The midbrain–hindbrain organizer (MHO) is a signalling centre that orchestrates development of the mesencephalic and anterior metencephalic primordia. In recent years, details have been revealed about the molecular nature of these signals, their transmission and reception, and the regulatory processes associated with MHO function. This article reviews recent progress in understanding the genetic and molecular components of the MHO, and how they synergize to control brain development.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping