PUBLICATION
Divide et Impera – the midbrain–hindbrain boundary and its organizer
- Authors
- Raible, F., and Brand, M.
- ID
- ZDB-PUB-041101-5
- Date
- 2004
- Source
- Trends in neurosciences 27(12): 727-734 (Review)
- Registered Authors
- Brand, Michael, Raible, Florian
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Evolution
- Gene Expression Regulation, Developmental
- Growth Substances/metabolism
- Mesencephalon*/anatomy & histology
- Mesencephalon*/embryology
- Mesencephalon*/physiology
- Morphogenesis
- Neurons/physiology
- Organizers, Embryonic*
- Rhombencephalon*/anatomy & histology
- Rhombencephalon*/embryology
- Rhombencephalon*/physiology
- Signal Transduction/physiology
- PubMed
- 15541513 Full text @ Trends Neurosci.
Citation
Raible, F., and Brand, M. (2004) Divide et Impera – the midbrain–hindbrain boundary and its organizer. Trends in neurosciences. 27(12):727-734.
Abstract
The midbrain–hindbrain organizer (MHO) is a signalling centre that orchestrates development of the mesencephalic and anterior metencephalic primordia. In recent years, details have been revealed about the molecular nature of these signals, their transmission and reception, and the regulatory processes associated with MHO function. This article reviews recent progress in understanding the genetic and molecular components of the MHO, and how they synergize to control brain development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping