|ZFIN ID: ZDB-PUB-041018-1|
Larval melanocyte regeneration following laser ablation in zebrafish
Yang, C.T., Sengelmann, R.D., and Johnson, S.L.
|Source:||The Journal of investigative dermatology 123(5): 924-929 (Journal)|
|Registered Authors:||Johnson, Stephen L., Yang, Chao-Tsung|
|PubMed:||15482481 Full text @ J. Invest. Dermatol.|
Yang, C.T., Sengelmann, R.D., and Johnson, S.L. (2004) Larval melanocyte regeneration following laser ablation in zebrafish. The Journal of investigative dermatology. 123(5):924-929.
ABSTRACTA method to specifically ablate melanocytes in a genetically tractable organism would facilitate the analysis of melanocyte regeneration and regulation. We have demonstrated that a Q-switched neodymium:yttrium-aluminum-garnet dermatology laser kills larval melanocytes in zebrafish. Following melanocyte ablation, new melanocytes regenerate from unpigmented precursors. We show that melanocyte regeneration following laser ablation requires kit receptor tyrosine kinase.
ADDITIONAL INFORMATION No data available