ZFIN ID: ZDB-PUB-041018-1
Larval melanocyte regeneration following laser ablation in zebrafish
Yang, C.T., Sengelmann, R.D., and Johnson, S.L.
Date: 2004
Source: The Journal of investigative dermatology   123(5): 924-929 (Journal)
Registered Authors: Johnson, Stephen L., Yang, Chao-Tsung
Keywords: none
MeSH Terms:
  • Animals
  • Cell Division/physiology
  • Lasers
  • Melanocytes/cytology*
  • Melanocytes/physiology*
  • Proto-Oncogene Proteins c-kit/physiology
  • Regeneration/physiology*
  • Skin/cytology
  • Skin/growth & development
  • Skin Physiological Phenomena*
  • Skin Pigmentation/physiology
  • Zebrafish
PubMed: 15482481 Full text @ J. Invest. Dermatol.
A method to specifically ablate melanocytes in a genetically tractable organism would facilitate the analysis of melanocyte regeneration and regulation. We have demonstrated that a Q-switched neodymium:yttrium-aluminum-garnet dermatology laser kills larval melanocytes in zebrafish. Following melanocyte ablation, new melanocytes regenerate from unpigmented precursors. We show that melanocyte regeneration following laser ablation requires kit receptor tyrosine kinase.