ZFIN ID: ZDB-PUB-041018-1
Larval melanocyte regeneration following laser ablation in zebrafish
Yang, C.T., Sengelmann, R.D., and Johnson, S.L.
A method to specifically ablate melanocytes in a genetically tractable organism would facilitate the analysis of melanocyte regeneration and regulation. We have demonstrated that a Q-switched neodymium:yttrium-aluminum-garnet dermatology laser kills larval melanocytes in zebrafish. Following melanocyte ablation, new melanocytes regenerate from unpigmented precursors. We show that melanocyte regeneration following laser ablation requires kit receptor tyrosine kinase.
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