PUBLICATION
Eph receptors and ephrins: effectors of morphogenesis
- Authors
- Holder, N., and Klein, R.
- ID
- ZDB-PUB-040827-1
- Date
- 1999
- Source
- Development (Cambridge, England) 126(10): 2033-2044 (Review)
- Registered Authors
- Holder, Nigel
- Keywords
- Eph receptors, Ephrins, Morphogenesis
- MeSH Terms
-
- Animals
- Cell Transformation, Neoplastic
- Ephrin-A1
- Humans
- Morphogenesis
- Proteins/metabolism*
- Receptor Protein-Tyrosine Kinases/metabolism*
- Signal Transduction*
- PubMed
- 10207129 Full text @ Development
Citation
Holder, N., and Klein, R. (1999) Eph receptors and ephrins: effectors of morphogenesis. Development (Cambridge, England). 126(10):2033-2044.
Abstract
Eph receptor tyrosine kinases and their ligands, the ephrins, appear to lie functionally at the interface between pattern formation and morphogenesis. We review the role of Eph and ephrin signalling in the formation of segmented structures, in the control of axon guidance and cell migration and in the development of the vasculature. We address the question of how the specificity of response is achieved and discuss the specificity of ephrin-Eph interactions and the significance of structural domains in Eph receptors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping