PUBLICATION
Genetic approaches to disease and regeneration
- Authors
- Keating, M.T.
- ID
- ZDB-PUB-040810-1
- Date
- 2004
- Source
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences 359(1445): 795-798 (Journal)
- Registered Authors
- Keating, Mark T.
- Keywords
- heart, regeneration, elastin, msx
- MeSH Terms
-
- Animals
- Cardiovascular Diseases/etiology*
- Cardiovascular Diseases/therapy
- Cell Differentiation/physiology
- Coronary Vessels/metabolism
- Disease Models, Animal
- Elastin/deficiency
- Elastin/metabolism*
- Elastin/therapeutic use
- Heart/physiology*
- Humans
- Muscle, Smooth/metabolism*
- Regeneration/genetics*
- Regeneration/physiology*
- Zebrafish
- PubMed
- 15293807 Full text @ Phil. Trans. Roy. Soc. Lond., Series B
Citation
Keating, M.T. (2004) Genetic approaches to disease and regeneration. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 359(1445):795-798.
Abstract
Cardiovascular disease is largely a consequence of coronary artery blockage through excessive proliferation of smooth muscle cells. It in turn leads to myocardial infarction and permanent and functionally devastating tissue damage to the heart wall. Our studies have revealed that elastin is a primary player in maintaining vascular smooth muscle cells in their dormant state and thus may be a useful therapeutic in vascular disease. By studying zebrafish, which unlike humans, can repair damage to heart muscle, we have begun to uncover some of the genes that seem necessary to undertake the de-differentiation steps that currently fail and prevent the formation of new proliferating cardiomyocytes at the site of damage in a mammalian heart.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping