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ZFIN ID: ZDB-PUB-040713-4
New models for the study of Mycobacterium-host interactions
Pozos, T.C., and Ramakrishnan, L.
Date: 2004
Source: Current opinion in immunology   16(4): 499-505 (Review)
Registered Authors: Pozos, Tamara Christine, Ramakrishnan, Lalita
Keywords: none
MeSH Terms:
  • Animals
  • Cell Movement/immunology
  • Diagnostic Imaging
  • Dictyostelium*/microbiology
  • Disease Models, Animal*
  • Drosophila/immunology*
  • Drosophila/microbiology
  • Granuloma/immunology
  • Granuloma/microbiology
  • Granuloma/pathology
  • Humans
  • Mice
  • Mycobacterium Infections/immunology*
  • Mycobacterium Infections/microbiology
  • Mycobacterium Infections/pathology
  • Mycobacterium marinum/immunology*
  • Mycobacterium tuberculosis/immunology*
  • Signal Transduction/immunology
  • Zebrafish/embryology
  • Zebrafish/immunology*
  • Zebrafish/microbiology
PubMed: 15245746 Full text @ Curr. Opin. Immunol.
The outcome of Mycobacterium infection is determined by a series of complex interactions between the bacteria and host immunity. Traditionally, mammalian models and cultured cells have been used to study these interactions. Recently, ameba (Dictyostelium), fruit flies (Drosophila) and zebrafish, amenable to forward genetic screens, have been developed as models for mycobacterial pathogenesis. Infection of these hosts with mycobacteria has allowed the dissection of intracellular trafficking pathways (Dictyostelium) and the roles of phagocytic versus antimicrobial peptide responses (Drosophila). Real-time visualization of the optically transparent zebrafish embryo/larva has elucidated mechanisms by which Mycobacterium-infected leukocytes migrate and subsequently aggregate into granulomas, the hallmark pathological structures of tuberculosis.