PUBLICATION
Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits
- Authors
- Bhatt, D.H., Otto, S.J., Depoister, B. and Fetcho, J.R.
- ID
- ZDB-PUB-040709-1
- Date
- 2004
- Source
- Science (New York, N.Y.) 305(5681): 254-258 (Journal)
- Registered Authors
- Bhatt, Dimple, Fetcho, Joseph R.
- Keywords
- none
- MeSH Terms
-
- Axons/drug effects
- Axons/physiology*
- Interneurons/physiology
- Bucladesine/pharmacology*
- Escape Reaction
- Animals
- Fluorescent Dyes
- Neurons/drug effects
- Neurons/physiology*
- Spinal Cord/cytology*
- Zebrafish
- Calcium/metabolism
- Rhodamines
- Regeneration
- Electroporation
- Nerve Regeneration*
- Spinal Cord Injuries/drug therapy*
- Spinal Cord Injuries/physiopathology*
- Microscopy, Confocal
- Cyclic AMP/analogs & derivatives
- Cyclic AMP/pharmacology
- PubMed
- 15247482 Full text @ Science
Citation
Bhatt, D.H., Otto, S.J., Depoister, B. and Fetcho, J.R. (2004) Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits. Science (New York, N.Y.). 305(5681):254-258.
Abstract
to regenerate, as a result of both an inhibitory environment and their inherent inability to regrow. In contrast, the CNS environment in fish is permissive for growth, yet some neurons still cannot regenerate. Fish thus offer an opportunity to study molecules that might surmount the intrinsic limitations they share with mammals, without the complication of an inhibitory environment. We show by in vivo imaging in zebrafish that post-injury application of cyclic adenosine monophosphate can transform severed CNS neurons into ones that regenerate and restore function, thus overcoming intrinsic limitations to regeneration in a vertebrate.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping