PUBLICATION

Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases

Authors
Zhang, H., Meng, L.H., Zimonjic, D.B., Popescu, N.C., and Pommier, Y.
ID
ZDB-PUB-040624-1
Date
2004
Source
Nucleic acids research   32(7): 2087-2092 (Journal)
Registered Authors
Keywords
none
MeSH Terms
  • Vertebrates/genetics
  • Humans
  • Evolution, Molecular*
  • In Situ Hybridization, Fluorescence
  • Animals
  • Amino Acid Sequence
  • Molecular Sequence Data
  • Gene Duplication
  • DNA Topoisomerases, Type I/genetics*
  • Amino Acid Motifs
  • Mitochondria/enzymology*
  • Mitochondria/genetics
  • Exons/genetics*
  • Cell Nucleus/enzymology*
  • Cluster Analysis
  • Conserved Sequence/genetics
(all 16)
PubMed
15096574 Full text @ Nucleic Acids Res.
Abstract
DNA topoisomerases contribute to various cellular activities that involve DNA. We previously identified a human nuclear gene that encodes a mitochondrial DNA topoisomerase. Here we show that genes for mitochondrial DNA topoisomerases (type IB) exist only in vertebrates. A 13-exon topoisomerase motif was identified as a characteristic of genes for both nuclear and mitochondrial type IB topoisomerases. The presence of this signature motif is thus an indicator of the coexistence of nuclear and mitochondrial type IB DNA topoisomerases. We hypothesize that the prototype topoisomerase IB with the 13-exon structure formed first, and then duplicated. One topoisomerase specialized for nuclear DNA and the other for mitochondrial DNA.
Genes / Markers
Figures
No images available
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Zhang, H., Meng, L.H., Zimonjic, D.B., Popescu, N.C., and Pommier, Y. (2004) Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases. Nucleic acids research. 32(7):2087-2092.