PUBLICATION
Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases
- Authors
- Zhang, H., Meng, L.H., Zimonjic, D.B., Popescu, N.C., and Pommier, Y.
- ID
- ZDB-PUB-040624-1
- Date
- 2004
- Source
- Nucleic acids research 32(7): 2087-2092 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Cell Nucleus/enzymology*
- Cluster Analysis
- Conserved Sequence/genetics
- DNA Topoisomerases, Type I/genetics*
- Evolution, Molecular*
- Exons/genetics*
- Gene Duplication
- Humans
- In Situ Hybridization, Fluorescence
- Mitochondria/enzymology*
- Mitochondria/genetics
- Molecular Sequence Data
- Vertebrates/genetics
- PubMed
- 15096574 Full text @ Nucleic Acids Res.
Citation
Zhang, H., Meng, L.H., Zimonjic, D.B., Popescu, N.C., and Pommier, Y. (2004) Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases. Nucleic acids research. 32(7):2087-2092.
Abstract
DNA topoisomerases contribute to various cellular activities that involve DNA. We previously identified a human nuclear gene that encodes a mitochondrial DNA topoisomerase. Here we show that genes for mitochondrial DNA topoisomerases (type IB) exist only in vertebrates. A 13-exon topoisomerase motif was identified as a characteristic of genes for both nuclear and mitochondrial type IB topoisomerases. The presence of this signature motif is thus an indicator of the coexistence of nuclear and mitochondrial type IB DNA topoisomerases. We hypothesize that the prototype topoisomerase IB with the 13-exon structure formed first, and then duplicated. One topoisomerase specialized for nuclear DNA and the other for mitochondrial DNA.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping