PUBLICATION
Expression pattern of the homeobox gene Not in the basal metazoan Trichoplax adhaerens
- Authors
- Martinelli, C., and Spring, J.
- ID
- ZDB-PUB-040609-6
- Date
- 2004
- Source
- Gene expression patterns : GEP 4(4): 443-447 (Journal)
- Registered Authors
- Keywords
- Homeobox, Homeodomain, Hox, non-Hox, ANTP, Not gene, Gsx, Trichoplax adhaerens, Placozoa, Basal metazoans, eh1 transcription repressor motif, Evolution, Regeneration, Diploblasts, Triploblasts, Bilateria
- MeSH Terms
-
- Phylogeny*
- Sequence Alignment
- Evolution, Molecular*
- Gene Expression Regulation/genetics
- Gene Expression Regulation/physiology*
- Molecular Sequence Data
- Amino Acid Sequence
- Animals
- Humans
- Invertebrates/genetics
- Transcription Factors/biosynthesis*
- Transcription Factors/genetics
- Homeodomain Proteins/biosynthesis*
- Homeodomain Proteins/genetics
- PubMed
- 15183311 Full text @ Gene Expr. Patterns
Citation
Martinelli, C., and Spring, J. (2004) Expression pattern of the homeobox gene Not in the basal metazoan Trichoplax adhaerens. Gene expression patterns : GEP. 4(4):443-447.
Abstract
The homeobox gene Not is highly conserved in Xenopus, chicken and zebrafish with an apparent role in notochord formation, which inspired the name of this distinct subfamily. Interestingly, Not genes are also well conserved in animals without notochord such as sea urchins, Drosophila or even Hydra, but appear to be highly derived in mammals. A search for homeobox genes in the placozoan Trichoplax adhaerens, one of the simplest organisms available today, revealed only two homeobox genes: a Not homologue and the previously described gene Trox-2, which is most similar to the Gsx subfamily of the Hox/ParaHox cluster genes. Not has a unique expression profile in Trichoplax. It is highly expressed in folds of intact animals and in the wounds of regenerating animals. The dynamic expression pattern of Trichoplax Not is discussed in comparison with the invariable expression pattern of Trox-2 and the putative secreted protein Secp1. The high sequence conservation of Not from Trichoplax to lower vertebrates, but not to mammals, represents a rare example of an apparent gene decay in the lineage leading to humans.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping