PUBLICATION
Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish
- Authors
- Bae, Y.K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M.
- ID
- ZDB-PUB-040609-5
- Date
- 2004
- Source
- Gene expression patterns : GEP 4(4): 481-486 (Journal)
- Registered Authors
- Bae, Young Ki, Hibi, Masahiko, Hirata, Tsutomu, Muraoka, Osamu, Nojima, Hideaki, Shimizu, Takashi, Yabe, Taijirou
- Keywords
- Homeobox, Neuroectoderm, Floor plate, Zebrafish
- MeSH Terms
-
- Animals
- Central Nervous System/embryology*
- Gene Expression Regulation, Developmental/genetics
- Gene Expression Regulation, Developmental/physiology*
- Homeodomain Proteins/biosynthesis*
- Homeodomain Proteins/genetics
- Humans
- Molecular Sequence Data
- Nodal Protein
- Signal Transduction/physiology
- Transcription Factors/biosynthesis*
- Transcription Factors/genetics
- Transforming Growth Factor beta/metabolism
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish Proteins/biosynthesis*
- Zebrafish Proteins/genetics
- PubMed
- 15183316 Full text @ Gene Expr. Patterns
Citation
Bae, Y.K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M. (2004) Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Gene expression patterns : GEP. 4(4):481-486.
Abstract
sax1/nkx1.2 and sax2/nkx1.1 are members of the evolutionally conserved NK-1 homeobox gene family. sax1/nkx1.2 is reported to be expressed in the central nervous system during early and late neurogenesis in the chick and mouse, but the expression of sax2/nkx1.1 has not been reported. We isolated zebrafish cDNAs for sax1/nkx1.2 and sax2/nkx1.1 and examined their expression. In zebrafish, unlike chick and mouse, sax1/nkx1.2 was expressed in the prospective medial floor plate from the mid-gastrula period and was dependent on Nodal signaling. From the early segmentation period, sax1/nkx1.2 was also expressed in the posterior neuroectoderm. sax2/nkx1.1 was expressed in the prospective extraocular muscles, mesencephalic neurons residing along the tract of the posterior commissure, ventral neurons in the hindbrain, and interneurons in the spinal cord.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping