PUBLICATION
Continuous tooth replacement: the possible involvement of epithelial stem cells
- Authors
- Huysseune, A., and Thesleff, I.
- ID
- ZDB-PUB-040604-4
- Date
- 2004
- Source
- BioEssays : news and reviews in molecular, cellular and developmental biology 26(6): 665-671 (Journal)
- Registered Authors
- Huysseune, Ann
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Differentiation
- Epithelial Cells/cytology*
- Epithelium/pathology
- Fishes
- Gene Expression Regulation, Developmental
- Mice
- Models, Biological
- Rats
- Stem Cells/cytology*
- Tooth/cytology*
- Tooth Germ/pathology
- Zebrafish
- PubMed
- 15170864 Full text @ Bioessays
Citation
Huysseune, A., and Thesleff, I. (2004) Continuous tooth replacement: the possible involvement of epithelial stem cells. BioEssays : news and reviews in molecular, cellular and developmental biology. 26(6):665-671.
Abstract
Epithelial stem cells have been identified in integumental structures such as hairs and continuously growing teeth of various rodents, and in the gut. Here we propose the involvement of epithelial stem cells in the continuous tooth replacement that characterizes non-mammalian vertebrates, as exemplified by the zebrafish. Arguments are based on morphological observations of tooth renewal in the zebrafish and on the similarities between molecular control of hair and tooth formation. Dissection of the molecular cascades underlying the regulation of the epithelial stem cell niche might open perspectives for new regenerative treatment strategies in clinical dentistry. BioEssays 26:665-671, 2004. Copyright 2004 Wiley Periodicals, Inc.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping