PUBLICATION
Towing of sensory axons by their migrating target cells in vivo
- Authors
- Gilmour, D., Knaut, H., Maischein, H.M., and Nüsslein-Volhard, C.
- ID
- ZDB-PUB-040421-3
- Date
- 2004
- Source
- Nature Neuroscience 7(5): 491-492 (Journal)
- Registered Authors
- Gilmour, Darren, Knaut, Holger, Maischein, Hans-Martin, Nüsslein-Volhard, Christiane
- Keywords
- none
- MeSH Terms
-
- Transplantation/methods
- Signal Transduction
- Growth Cones
- Zebrafish
- Zebrafish Proteins/genetics
- Embryo, Nonmammalian
- Time Factors
- In Situ Hybridization/methods
- Cell Communication/genetics*
- Receptors, CXCR4/genetics
- Animals, Genetically Modified
- Chemokines, CXC/metabolism
- Animals
- Axons/physiology*
- Cell Movement/physiology*
- Green Fluorescent Proteins
- Diagnostic Imaging/methods
- Chemokine CXCL12
- Neurons, Afferent/cytology
- Neurons, Afferent/physiology*
- Neurons, Afferent/transplantation
- Luminescent Proteins
- PubMed
- 15097993 Full text @ Nat. Neurosci.
Citation
Gilmour, D., Knaut, H., Maischein, H.M., and Nüsslein-Volhard, C. (2004) Towing of sensory axons by their migrating target cells in vivo. Nature Neuroscience. 7(5):491-492.
Abstract
Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping