PUBLICATION

Towing of sensory axons by their migrating target cells in vivo

Authors
Gilmour, D., Knaut, H., Maischein, H.M., and Nüsslein-Volhard, C.
ID
ZDB-PUB-040421-3
Date
2004
Source
Nature Neuroscience   7(5): 491-492 (Journal)
Registered Authors
Gilmour, Darren, Knaut, Holger, Maischein, Hans-Martin, Nüsslein-Volhard, Christiane
Keywords
none
MeSH Terms
  • Axons/physiology*
  • Zebrafish
  • Animals
  • Animals, Genetically Modified
  • Luminescent Proteins
  • Zebrafish Proteins/genetics
  • Cell Communication/genetics*
  • Diagnostic Imaging/methods
  • Green Fluorescent Proteins
  • Neurons, Afferent/cytology
  • Neurons, Afferent/physiology*
  • Neurons, Afferent/transplantation
  • Embryo, Nonmammalian
  • Signal Transduction
  • Growth Cones
  • Cell Movement/physiology*
  • Chemokines, CXC/metabolism
  • Receptors, CXCR4/genetics
  • Chemokine CXCL12
  • Time Factors
  • Transplantation/methods
  • In Situ Hybridization/methods
PubMed
15097993 Full text @ Nat. Neurosci.
Abstract
Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping