Muscle differentiation: a gene for slow muscle?
- Hughes, S.M.
- Current biology : CB 14(4): 156-157 (Journal)
- Registered Authors
- Hughes, Simon M.
- MeSH Terms
- Cell Differentiation
- DNA-Binding Proteins
- Gene Expression Regulation
- Hedgehog Proteins
- Muscle Development*
- Muscle Fibers, Slow-Twitch/metabolism
- Muscle Fibers, Slow-Twitch/physiology*
- Muscle, Skeletal/embryology*
- Myoblasts, Skeletal/cytology*
- Nuclear Proteins
- Repressor Proteins/genetics
- Repressor Proteins/metabolism*
- Transcription Factors/genetics
- Transcription Factors/metabolism*
- Zebrafish Proteins
- 15027468 Full text @ Curr. Biol.
Hughes, S.M. (2004) Muscle differentiation: a gene for slow muscle?. Current biology : CB. 14(4):156-157.
Skeletal muscle comes in two fundamental flavours, slow and fast, which determine physiological performance. Zebrafish screens have provided a handle on the molecular mechanism driving slow muscle formation. The transcriptional repressor Blimp1 has now been shown to be required in embryonic slow muscle precursor cells.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes