PUBLICATION

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor

Authors
Slack, F.J., Basson, M., Liu, Z., Ambros, V., Horvitz, H.R., and Ruvkun, G.
ID
ZDB-PUB-040126-1
Date
2000
Source
Molecular Cell   5(4): 659-669 (Journal)
Registered Authors
Keywords
none
MeSH Terms
  • Genes, Helminth*
  • Mutation
  • RNA, Helminth/metabolism*
  • Amino Acid Sequence
  • Zinc Fingers
  • Alleles
  • Animals
  • Gene Expression Regulation, Developmental
  • 3' Untranslated Regions
  • Time Factors
  • Tissue Distribution
  • Base Sequence
  • DNA-Binding Proteins/metabolism*
  • Helminth Proteins/metabolism
  • Multigene Family
  • Body Patterning/genetics*
  • Molecular Sequence Data
  • Caenorhabditis elegans/embryology*
  • Caenorhabditis elegans/genetics
  • Transcription Factors/genetics
  • Transcription Factors/metabolism*
  • Down-Regulation
  • Caenorhabditis elegans Proteins*
(all 23)
PubMed
10882102 Full text @ Mol. Cell
Abstract
Null mutations in the C. elegans heterochronic gene lin-41 cause precocious expression of adult fates at larval stages. Increased lin-41 activity causes the opposite phenotype, reiteration of larval fates. let-7 mutations cause similar reiterated heterochronic phenotypes that are suppressed by lin-41 mutations, showing that lin-41 is negatively regulated by let-7. lin-41 negatively regulates the timing of LIN-29 adult specification transcription factor expression. lin-41 encodes an RBCC protein, and two elements in the lin-413'UTR are complementary to the 21 nucleotide let-7 regulatory RNA. A lin-41::GFP fusion gene is downregulated in the tissues affected by lin-41 at the time that the let-7 regulatory RNA is upregulated. We suggest that late larval activation of let-7 RNA expression downregulates LIN-41 to relieve inhibition of lin-29.
Genes / Markers
Figures
No images available
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Slack, F.J., Basson, M., Liu, Z., Ambros, V., Horvitz, H.R., and Ruvkun, G. (2000) The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Molecular Cell. 5(4):659-669.