PUBLICATION
Steps during the development of the zebrafish locomotor network
- Authors
- Brustein, E., Saint-Amant, L., Buss, R.R., Chong, M., McDearmid, J.R., and Drapeau, P.
- ID
- ZDB-PUB-040109-13
- Date
- 2003
- Source
- Journal of physiology, Paris 97(1): 77-86 (Journal)
- Registered Authors
- Brustein, Edna, Buss, Robert, Chong, Mabel, Drapeau, Pierre, McDearmid, Joe, Saint-Amant, Louis
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified/physiology
- Behavior, Animal
- Embryo, Nonmammalian
- Larva
- Motor Activity/genetics
- Motor Activity/physiology*
- Mutagenicity Tests/methods
- Nerve Net/embryology
- Nerve Net/physiology*
- Neurons/classification
- Neurons/physiology*
- Zebrafish/embryology
- Zebrafish/physiology*
- PubMed
- 14706693 Full text @ J. Physiol. Paris
Citation
Brustein, E., Saint-Amant, L., Buss, R.R., Chong, M., McDearmid, J.R., and Drapeau, P. (2003) Steps during the development of the zebrafish locomotor network. Journal of physiology, Paris. 97(1):77-86.
Abstract
This review summarizes recent data from our lab concerning the development of motor activities in the developing zebrafish. The zebrafish is a leading model for studies of vertebrate development because one can obtain a large number of transparent, externally and rapidly developing embryos with motor behaviors that are easy to assess (e.g. for mutagenic screens). The emergence of embryonic motility was studied behaviorally and at the cellular level. The embryonic behaviors appear sequentially and include an early, transient period of spontaneous, alternating tail coilings, followed by responses to touch, and swimming. Patch clamp recording in vivo revealed that an electrically coupled network of a subset of spinal neurons generates spontaneous tail coiling, whereas a chemical (glutamatergic and glycinergic) synaptic drive underlies touch responses and swimming and requires input from the hindbrain. Swimming becomes sustained in larvae once serotonergic neuromodulatory effects are integrated. We end with a brief overview of the genetic tools available for the study of the molecular determinants implicated in locomotor network development in the zebrafish. Combining genetic, behavioral and cellular experimental approaches will advance our understanding of the general principles of locomotor network assembly and function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping