|ZFIN ID: ZDB-PUB-031218-1|
Embryo morphogenesis: getting down to cells and molecules
Solnica-Krezel, L. and Eaton, S.
|Source:||Development (Cambridge, England) 130(18): 4229-4233 (Review)|
|Registered Authors:||Solnica-Krezel, Lilianna|
|PubMed:||12900440 Full text @ Development|
Solnica-Krezel, L. and Eaton, S. (2003) Embryo morphogenesis: getting down to cells and molecules. Development (Cambridge, England). 130(18):4229-4233.
ABSTRACTAfter the molecular cloning revolution in the 1980s, the field of developmental biology became focused on the regulation of gene expression as a framework for understanding the specification of cell fate. The advent of sequenced genomes and comprehensive microarrays has removed the last obstacle to cataloguing the molecules that orchestrate development, and one challenge for the future will be to put them in their cellular and embryological context. The title of the workshop that took place at the Juan March Institute (Madrid, Spain) in May this year, "The dynamics of morphogenesis: regulation of cell and tissue movements in development", which was organized by Claudio Stern (UCL, London, UK) and Angela Nieto (Instituto Cajal, Madrid, Spain), exemplifies this change in emphasis. Many of the talks reflected the increasing communication of ideas and techniques between cell and developmental biologists, and the advances in live imaging techniques that have allowed the field to refocus on the cell as the unit of morphogenesis. While developmental biologists clearly have a lot to gain from taking a more cell biological approach, some of the astonishing cell behaviors observed in developing organisms should provide cell biologists with more interesting problems than those presented in a culture dish.
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