PUBLICATION

Zebrafish pronephros: A model for understanding cystic kidney disease

Authors
Hostetter, C.L., Sullivan-Brown, J.L., and Burdine, R.D.
ID
ZDB-PUB-031031-14
Date
2003
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   228(3): 514-522 (Review)
Registered Authors
Burdine, Rebecca, Hostetter, Christine, Sullivan-Brown, Jessica
Keywords
zebrafish, pronephros, cystic, kidney, asymmetry
MeSH Terms
  • Animals
  • Body Patterning/physiology*
  • Kidney/abnormalities
  • Kidney/embryology*
  • Kidney Diseases, Cystic*
  • Models, Animal
  • Morphogenesis
  • Zebrafish/embryology*
PubMed
14579389 Full text @ Dev. Dyn.
Abstract
The embryonic kidney of the zebrafish is the pronephros. The ease of genetic analysis and experimentation in zebrafish, coupled with the simplicity of the pronephros, make the zebrafish an ideal model system for studying kidney development and function. Several mutations have been isolated in zebrafish genetic screens that result in cyst formation in the pronephros. Cloning and characterization of these mutations will provide insight into kidney development but may also provide understanding of the molecular basis of cystic kidney diseases. In this review, we focus on the zebrafish as a model for understanding cystic kidney disease and the links between cystic kidney disease and left-right patterning.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping