PUBLICATION
Generating X: formation of the optic chiasm
- Authors
- Rasband, K., Hardy, M., and Chien, C.-B.
- ID
- ZDB-PUB-031027-1
- Date
- 2003
- Source
- Neuron 39(6): 885-888 (Review)
- Registered Authors
- Chien, Chi-Bin, Rasband, Kendall
- Keywords
- none
- MeSH Terms
-
- Optic Chiasm/growth & development*
- Optic Chiasm/metabolism*
- Growth Substances/biosynthesis
- Growth Substances/genetics
- Humans
- Gene Expression Regulation, Developmental/physiology
- Animals
- PubMed
- 12971890 Full text @ Neuron
Citation
Rasband, K., Hardy, M., and Chien, C.-B. (2003) Generating X: formation of the optic chiasm. Neuron. 39(6):885-888.
Abstract
At the optic chiasm, axons from either eye meet and decide whether to cross contralaterally or turn back ipsilaterally. Here, the guidance ligand Slit and its receptor Robo control not whether axons cross (as in other midline decisions), but where the chiasm forms. Whether axons cross is instead controlled by the transcription factor Zic2 and the guidance receptor EphB1, as shown by two papers in the current issues of Neuron and Cell (Herrera et al. and Williams et al.). Surprisingly, this mechanism is conserved evolutionarily from frogs to mammals.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping