PUBLICATION
The Fem1c genes: conserved members of the Fem1 gene family in vertebrates
- Authors
- Ventura-Holman, T., Lu, D., Si, X., Izevbigie, E.B., and Maher, J.F.
- ID
- ZDB-PUB-031008-2
- Date
- 2003
- Source
- Gene 315: 133-139 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Chromosome Mapping
- Chromosomes, Human, Pair 5/genetics
- Cloning, Molecular
- Conserved Sequence/genetics
- DNA, Complementary/chemistry
- DNA, Complementary/genetics
- Exons
- Female
- Gene Expression
- Genes/genetics
- Humans
- Introns
- Male
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Proteins/genetics*
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Vertebrates/genetics*
- Zebrafish/genetics
- PubMed
- 14527725 Full text @ Gene
Citation
Ventura-Holman, T., Lu, D., Si, X., Izevbigie, E.B., and Maher, J.F. (2003) The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. Gene. 315:133-139.
Abstract
The fem-1 gene of Caenorhabditis elegans functions in a signaling pathway that controls sex determination. Homologs of fem-1 in mammals have been characterized, consisting of two family members, Fem1a and Fem1b. We report here on Fem1c, a third member of the Fem1 gene family, in three vertebrate species: human, mouse, and zebrafish. The proteins encoded by these Fem1c genes share >99% amino acid identity between human and mouse, 79% amino acid identity between mouse and zebrafish, and end with a C-terminal Arginine residue, which distinguishes them from other FEM-1 proteins reported thus far. The human and mouse Fem1c coding regions show conservation of intron-exon structure and expression pattern in adult tissues. Human FEM1C maps to 5q22, mouse Fem1c maps to chromosome 18, and zebrafish fem1c maps to Linkage Group 8. The Fem1c genes in vertebrates may play a conserved role in the development and/or physiologic function of these organisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping