PUBLICATION

The Fem1c genes: conserved members of the Fem1 gene family in vertebrates

Authors
Ventura-Holman, T., Lu, D., Si, X., Izevbigie, E.B., and Maher, J.F.
ID
ZDB-PUB-031008-2
Date
2003
Source
Gene   315: 133-139 (Journal)
Registered Authors
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Chromosome Mapping
  • Chromosomes, Human, Pair 5/genetics
  • Cloning, Molecular
  • Conserved Sequence/genetics
  • DNA, Complementary/chemistry
  • DNA, Complementary/genetics
  • Exons
  • Female
  • Gene Expression
  • Genes/genetics
  • Humans
  • Introns
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Proteins/genetics*
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Vertebrates/genetics*
  • Zebrafish/genetics
PubMed
14527725 Full text @ Gene
Abstract
The fem-1 gene of Caenorhabditis elegans functions in a signaling pathway that controls sex determination. Homologs of fem-1 in mammals have been characterized, consisting of two family members, Fem1a and Fem1b. We report here on Fem1c, a third member of the Fem1 gene family, in three vertebrate species: human, mouse, and zebrafish. The proteins encoded by these Fem1c genes share >99% amino acid identity between human and mouse, 79% amino acid identity between mouse and zebrafish, and end with a C-terminal Arginine residue, which distinguishes them from other FEM-1 proteins reported thus far. The human and mouse Fem1c coding regions show conservation of intron-exon structure and expression pattern in adult tissues. Human FEM1C maps to 5q22, mouse Fem1c maps to chromosome 18, and zebrafish fem1c maps to Linkage Group 8. The Fem1c genes in vertebrates may play a conserved role in the development and/or physiologic function of these organisms.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping