ZFIN ID: ZDB-PUB-031001-1
lunatic fringe regulates delta-notch induction of hypochord in zebrafish
Appel, B., Marasco, P., McClung, L.E., and Latimer, A.J.
Date: 2003
Source: Developmental dynamics : an official publication of the American Association of Anatomists   228(2): 281-286 (Journal)
Registered Authors: Appel, Bruce, Latimer, Andrew
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning
  • Cloning, Molecular
  • Gastrula
  • Gene Expression Regulation, Developmental/drug effects*
  • Glycosyltransferases/genetics
  • Glycosyltransferases/metabolism*
  • In Situ Hybridization
  • Intracellular Signaling Peptides and Proteins
  • Ligands
  • Membrane Proteins/genetics
  • Membrane Proteins/metabolism*
  • Notochord/physiology*
  • Oligonucleotides, Antisense/pharmacology
  • Receptors, Notch
  • Signal Transduction
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish Proteins/physiology
PubMed: 14518000 Full text @ Dev. Dyn.
Cells that occupy the midline of vertebrate embryos arise from a common population of precursors. Several lines of evidence indicate that Delta-Notch signaling regulates specification of midline precursors for different fates. We show that zebrafish midline precursors transiently express lunatic fringe, which encodes a glycosyltransferase that modifies Notch activity in response to its ligands, and that lunatic fringe function is required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain.