PUBLICATION

The development of the nervous system: from fly to fish, from fish to man

Authors
Ghysen, A. and Dambly-Chaudiere, C.
ID
ZDB-PUB-030910-9
Date
2003
Source
Med. Sci.   19(5): 575-581 (Review)
Registered Authors
Ghysen, Alain
Keywords
none
MeSH Terms
  • Animal Structures/embryology
  • Animals
  • Cell Movement
  • Drosophila melanogaster/embryology
  • Embryo, Nonmammalian/cytology
  • Gene Expression Regulation, Developmental
  • Humans
  • Models, Biological
  • Morphogenesis
  • Neoplasm Metastasis
  • Neurons/cytology
  • Organ Specificity
  • Receptors, CXCR4/physiology
  • Sense Organs/cytology
  • Sense Organs/embryology*
  • Species Specificity
  • Vertebrates/embryology
  • Zebrafish/embryology*
PubMed
12836391 Full text @ Med. Sci.
Abstract
The nervous system of vertebrates is more complex and less tractable than that of current model organisms such as the fly and the nematode. Here we present a vertebrate sensory system which is structurally simple, experimentally accessible and genetically suitable: the lateral line of the zebra-fish. We review our recent work on the development of this system, with a particular emphasis on the migration events that shape the pattern of sense organs. Some of the factors involved in these migration events turn out to be similar to the factors that direct the formation of metastases in specific types of human cancers, illustrating once again the remarkable conservation of developmental mechanisms and genes throughout the animal kingdom.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes
[Article in French]