PUBLICATION
Comparative mapping of Z-orthologous genes in vertebrates: implications for the evolution of avian sex chromosomes
- Authors
- Nanda, I., Haaf, T., Schartl, M., Schmid, M., and Burt, D.W.
- ID
- ZDB-PUB-030806-4
- Date
- 2002
- Source
- Cytogenetic and genome research 99(1-4): 178-184 (Journal)
- Registered Authors
- Schartl, Manfred
- Keywords
- none
- MeSH Terms
-
- Animals
- Chickens
- Chromosome Mapping
- Evolution, Molecular*
- Humans
- Sex Chromosomes/genetics*
- Synteny
- Vertebrates/genetics*
- X Chromosome/genetics
- Y Chromosome/genetics
- PubMed
- 12900562 Full text @ Cytogenet. Genome Res.
Citation
Nanda, I., Haaf, T., Schartl, M., Schmid, M., and Burt, D.W. (2002) Comparative mapping of Z-orthologous genes in vertebrates: implications for the evolution of avian sex chromosomes. Cytogenetic and genome research. 99(1-4):178-184.
Abstract
Sex chromosomes of birds and mammals are highly differentiated and share several cytological features. However, comparative gene mapping reveals extensive conserved synteny between the chicken Z sex chromosome and human chromosome 9 but not the human X sex chromosome, implying an independent origin of avian and mammalian sex chromosomes. To better understand the evolution of the avian Z chromosome we analysed the synteny of chicken Z-linked genes in zebrafish, which is the best-mapped teleost genome so far. Existing zebrafish maps do not support the existence of an ancestral Z linkage group in the zebrafish genome, whereas mammalian X-linked genes show at least some degree of synteny conservation. This is consistent with in situ hybridisation mapping data in the freshwater pufferfish, TETRAODON NIGROVIRIDIS where mammalian X-linked genes show a much higher degree of conserved synteny than human chromosome 9 or the avian Z chromosome. Collectively, these data argue in favour of a more recent evolution of the avian Z chromosome, compared with the mammalian X.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping