|ZFIN ID: ZDB-PUB-030730-12|
An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm
Goering, L.M., Hoshijima, K., Hug, B., Bisgrove, B., Kispert, A., and Grunwald, D.J.
|Source:||Proceedings of the National Academy of Sciences of the United States of America 100(16): 9410-9415 (Journal)|
|Registered Authors:||Bisgrove, Brent, Goering, Lisa, Grunwald, David, Hoshijima, Kazuyuki, Hug, Barbara|
|PubMed:||12883008 Full text @ Proc. Natl. Acad. Sci. USA|
Goering, L.M., Hoshijima, K., Hug, B., Bisgrove, B., Kispert, A., and Grunwald, D.J. (2003) An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. Proceedings of the National Academy of Sciences of the United States of America. 100(16):9410-9415.
ABSTRACTT-box genes encode transcription factors that play critical roles in generating the vertebrate body plan. In many developmental fields, multiple T-box genes are expressed in overlapping domains, establishing broad regions in which different combinations of T-box genes are coexpressed. Here we demonstrate that three T-box genes expressed in the zebrafish mesoderm, no tail, spadetail, and tbx6, operate as a network of interacting genes to regulate region-specific gene expression and developmental fate. Loss-of-function and gain-of-function genetic analyses reveal three kinds of interactions among the T-box genes: combinatorial interactions that generate new regulatory functions, additive contributions to common developmental pathways, and competitive antagonism governing downstream gene expression. We propose that T-box genes, like Hox genes, often function within gene networks comprised of related family members.