PUBLICATION
Methoprene photolytic compounds disrupt zebrafish development, producing phenocopies of mutants in the sonic hedgehog signaling pathway
- Authors
- Smith, D.G., Wilburn, C., and McCarthy, R.A.
- ID
- ZDB-PUB-030728-15
- Date
- 2003
- Source
- Marine biotechnology (New York, N.Y.) 5(2): 201-212 (Journal)
- Registered Authors
- McCarthy, Robert, Smith, Denice
- Keywords
- none
- MeSH Terms
-
- Embryo, Nonmammalian/drug effects
- Hormones/radiation effects
- Hormones/toxicity
- Embryonic Induction/genetics
- Hedgehog Proteins
- Juvenile Hormones/radiation effects
- Juvenile Hormones/toxicity
- Gene Expression Regulation, Developmental/drug effects
- Trans-Activators/genetics*
- Pesticides/radiation effects
- Pesticides/toxicity
- Zebrafish/abnormalities*
- Signal Transduction/genetics*
- Photolysis*
- Animals
- Embryonic Development
- Mutation
- Phenotype
- Methoprene/radiation effects
- Methoprene/toxicity*
- PubMed
- 12876657 Full text @ Mar. Biotechnol.
Citation
Smith, D.G., Wilburn, C., and McCarthy, R.A. (2003) Methoprene photolytic compounds disrupt zebrafish development, producing phenocopies of mutants in the sonic hedgehog signaling pathway. Marine biotechnology (New York, N.Y.). 5(2):201-212.
Abstract
Environmental chemicals have been proposed to impact endocrine or retinoid pathways, causing developmental abnormalities in humans and other vertebrates. Presented evidence shows that exposure of zebrafish embryos to sunlight-induced photolytic products of the pesticide methoprene results in developmental defects in the head, heart, pectoral fins, and somites, and in spinal motor and optic nerve axons. Exposed embryos are phenocopies of zebrafish you-type mutants and, as in the mutant sonic-you, show underexpression of the signaling protein sonic hedgehog. Reduced expression of sonic hedgehog is also displayed in embryos treated with the retinoic acid synthesis inhibitor citral. This study identifies citral-related compounds as embryonic signaling disruptors of potential environmental concern.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping