PUBLICATION
Leaning to the left: laterality in the zebrafish forebrain
- Authors
- Halpern, M.E., Liang, J.O., and Gamse, J.T.
- ID
- ZDB-PUB-030716-19
- Date
- 2003
- Source
- Trends in neurosciences 26(6): 308-313 (Journal)
- Registered Authors
- Gamse, Josh, Halpern, Marnie E., Liang, Jennifer
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning/genetics*
- Body Patterning/physiology
- Diencephalon/growth & development
- Diencephalon/metabolism
- Epithalamus/growth & development*
- Epithalamus/metabolism
- Functional Laterality/genetics
- Functional Laterality/physiology*
- Gene Expression Regulation, Developmental/physiology
- Learning/physiology
- Nodal Protein
- Organogenesis/genetics
- Organogenesis/physiology
- Signal Transduction/genetics
- Signal Transduction/physiology
- Transforming Growth Factor beta/genetics
- Zebrafish/genetics
- Zebrafish/growth & development*
- PubMed
- 12798600 Full text @ Trends Neurosci.
Citation
Halpern, M.E., Liang, J.O., and Gamse, J.T. (2003) Leaning to the left: laterality in the zebrafish forebrain. Trends in neurosciences. 26(6):308-313.
Abstract
How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the embryonic brain, to bias laterality of the epithalamus. Formation of an asymmetric pineal complex differentially influences adjacent diencephalic nuclei, the left and right habenulae, which acquire distinctive molecular and cellular features. Results from the genetically tractable zebrafish system provide a promising entry point for exploring how left-right biases are established and propagated in the developing vertebrate brain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping