| ZFIN ID: ZDB-PUB-030702-4 |
Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning
Malicki, J., Jo, H., and Pujic, Z.
| Date: | 2003 |
|---|---|
| Source: | Developmental Biology 259(1): 95-108 (Journal) |
| Registered Authors: | Jo, Hakryul, Malicki, Jarema, Pujic, Zac |
| Keywords: | none |
| MeSH Terms: |
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| PubMed: | 12812791 Full text @ Dev. Biol. |
Citation
Malicki, J., Jo, H., and Pujic, Z. (2003) Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning. Developmental Biology. 259(1):95-108.
ABSTRACT
Genetic screens in zebrafish identified several loci that play essential roles in the patterning of retinal architecture. Here, we show that one of them, glass onion, encodes the N-cadherin gene. The glo(m117) mutant allele contains a substitution of the Trp2 residue known for its essential role in the adhesive properties of classic cadherins. Both the glo(m117) and pac(tm101b) mutant N-cadherin alleles affect the polarity of the retinal neuroepithelial sheet and, unexpectedly, both result in cell-nonautonomous phenotypes in retinal patterning. The late onset of mutant N-cadherin phenotypes may be due to the ability of classic cadherins to substitute each other's function.
ADDITIONAL INFORMATION
- Genes / Markers (2)
- Mutations and Transgenics (2)
- Fish (2)
- Orthology (4)