ZFIN ID: ZDB-PUB-030702-4
Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning
Malicki, J., Jo, H., and Pujic, Z.
Date: 2003
Source: Developmental Biology   259(1): 95-108 (Journal)
Registered Authors: Jo, Hakryul, Malicki, Jarema, Pujic, Zac
Keywords: none
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Body Patterning
  • Cadherins/chemistry
  • Cadherins/genetics
  • Cadherins/physiology*
  • Chromosome Mapping
  • Female
  • Molecular Sequence Data
  • Mutation
  • Retina/embryology*
  • Zebrafish/embryology*
PubMed: 12812791 Full text @ Dev. Biol.
Genetic screens in zebrafish identified several loci that play essential roles in the patterning of retinal architecture. Here, we show that one of them, glass onion, encodes the N-cadherin gene. The glo(m117) mutant allele contains a substitution of the Trp2 residue known for its essential role in the adhesive properties of classic cadherins. Both the glo(m117) and pac(tm101b) mutant N-cadherin alleles affect the polarity of the retinal neuroepithelial sheet and, unexpectedly, both result in cell-nonautonomous phenotypes in retinal patterning. The late onset of mutant N-cadherin phenotypes may be due to the ability of classic cadherins to substitute each other's function.