PUBLICATION
Notch signaling: endocytosis makes delta signal better
- Authors
- Le Borgne, R. and Schweisguth, F.
- ID
- ZDB-PUB-030408-6
- Date
- 2003
- Source
- Current biology : CB 13(7): R273-275 (Review)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Intracellular Signaling Peptides and Proteins
- Endocytosis/genetics
- Endocytosis/physiology*
- Zebrafish Proteins/metabolism
- Membrane Proteins/genetics*
- Membrane Proteins/metabolism*
- Ubiquitin-Protein Ligases/metabolism
- Signal Transduction
- Animals
- Receptors, Cell Surface/metabolism*
- Zebrafish
- Gene Expression Regulation/genetics
- Gene Expression Regulation/physiology*
- Receptors, Notch
- Xenopus
- PubMed
- 12676105 Full text @ Curr. Biol.
Citation
Le Borgne, R. and Schweisguth, F. (2003) Notch signaling: endocytosis makes delta signal better. Current biology : CB. 13(7):R273-275.
Abstract
Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping